Pregnancy registry survey
One response per person, collected 2021-04-13 to 2021-06-07 (vsafe_pregnancy_registry_survey_20210413-20210607.xlsx). Age, vaccine, call center and hospital/ER flags come from each person's other v-safe records.
Screened out: respondents aged 51+ at their first dose (5,644 people) are left out of the tiles and charts, except the 1 with a pregnancy loss. 1,597 respondents had a pregnancy loss: the registrant’s own miscarriage, stillbirth, fetal demise, or ectopic, molar or chemical pregnancy, post vaccination, found in their own words or a MedDRA code. Not a loss they place before the vaccine, someone else’s loss, or a threatened or possible miscarriage. Some of them answered "not pregnant" after the loss.
Pregnancy respondents: the full list, with filters →
Comparison group: 3,221,439 women who registered in v-safe for themselves, aged 12-50 at their first dose, with no sign of pregnancy anywhere in v-safe. Their rates are age-standardized to the pregnant group they are compared with. Bars show percentages; the black lines are 95% confidence intervals.
Responses by week
Show the numbers
| Not pregnant at or since vaccination | Pregnant after vaccination | Pregnant at time of vaccination | |
|---|---|---|---|
| 2021-04-12 | 3,932 | 3,597 | 37,501 |
| 2021-04-19 | 1,392 | 1,454 | 9,376 |
| 2021-04-26 | 713 | 1,221 | 3,354 |
| 2021-05-03 | 440 | 916 | 1,939 |
| 2021-05-10 | 446 | 869 | 1,563 |
| 2021-05-17 | 372 | 701 | 1,414 |
| 2021-05-24 | 322 | 663 | 1,180 |
| 2021-05-31 | 43 | 90 | 122 |
| 2021-06-07 | 1 |
When the survey ran, split by the answer to "pregnancy status". Counts, after the age screen.
Which check-in reported the pregnancy loss
Show the numbers
| Dose 1 (n=245) | Dose 2 (n=644) | Dose 3+ (n=42) | |
|---|---|---|---|
| Day 0 | 0 | 10 | 0 |
| Days 1-6 | 48 | 86 | 1 |
| Day 7 | 19 | 30 | 0 |
| Week 2 | 68 | 110 | 2 |
| Week 3 | 55 | 105 | 0 |
| Week 4 | 18 | 74 | 0 |
| Week 5 | 9 | 55 | 2 |
| Week 6 | 6 | 50 | 4 |
| 3 months | 17 | 76 | 6 |
| 6 months | 4 | 38 | 13 |
| 12 months | 1 | 10 | 14 |
931 women pregnant at vaccination with a MedDRA loss code, by the check-in survey that first reported it, colored by the dose that check-in followed. v-safe has no loss date, only the check-in date. The later check-ins cover longer stretches: the 3-month survey picks up anything since week 6 (about 7 weeks), the 6-month survey about 13 weeks, and the 12-month survey about 26 weeks, so their bars hold more time than the weekly ones. Each dose started its own check-in schedule, and the old one mostly stopped. Dose 2 came 3–4 weeks after dose 1 (21 days for Pfizer, 28 for Moderna), so dose-1 check-ins fade after week 3, and the later check-ins are almost all on dose 2's schedule. The color shows which schedule was running when the loss was reported, not necessarily the dose closest to the loss.
Losses reported in the first week, by day
Show the numbers
| Dose 1 (n=48) | Dose 2 (n=96) | Dose 3+ (n=1) | |
|---|---|---|---|
| Day 0 | 0 | 10 | 0 |
| Day 1 | 0 | 6 | 0 |
| Day 2 | 6 | 13 | 0 |
| Day 3 | 6 | 15 | 1 |
| Day 4 | 12 | 16 | 0 |
| Day 5 | 10 | 20 | 0 |
| Day 6 | 14 | 16 | 0 |
The 145 of those losses reported in the day-0 or daily (days 1–6) check-ins, by days after the dose. Day 0 is the day of the shot.
How far along the pregnancy was at the loss
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| Weeks | Took the pregnancy survey | Did not | All |
|---|---|---|---|
| 2 | 1 | 5 | 6 |
| 3 | 2 | 3 | 5 |
| 4 | 9 | 14 | 23 |
| 5 | 21 | 48 | 69 |
| 6 | 36 | 59 | 95 |
| 7 | 28 | 41 | 69 |
| 8 | 46 | 51 | 97 |
| 9 | 29 | 55 | 84 |
| 10 | 24 | 29 | 53 |
| 11 | 17 | 22 | 39 |
| 12 | 10 | 28 | 38 |
| 13 | 6 | 9 | 15 |
| 14 | 3 | 10 | 13 |
| 15 | 6 | 5 | 11 |
| 16 | 6 | 10 | 16 |
| 17 | 5 | 6 | 11 |
| 18 | 8 | 7 | 15 |
| 19 | 6 | 5 | 11 |
| 20 | 7 | 7 | 14 |
| 21 | 3 | 1 | 4 |
| 22 | 7 | 3 | 10 |
| 23 | 1 | 2 | 3 |
| 24 | 2 | 3 | 5 |
| 25 | 4 | 1 | 5 |
| 26 | 0 | 0 | 0 |
| 27 | 2 | 0 | 2 |
| 28 | 2 | 0 | 2 |
| 29 | 0 | 3 | 3 |
| 30 | 1 | 0 | 1 |
| 31 | 0 | 0 | 0 |
| 32 | 1 | 0 | 1 |
| 33 | 0 | 1 | 1 |
| 34 | 0 | 1 | 1 |
| 35 | 1 | 1 | 2 |
| 36 | 1 | 3 | 4 |
| 37 | 1 | 2 | 3 |
| 38 | 1 | 1 | 2 |
| 39 | 1 | 1 | 2 |
| 40 | 0 | 0 | 0 |
| 41 | 0 | 1 | 1 |
| 42 | 0 | 0 | 0 |
From free text like "miscarriage at 7 weeks" or "stillborn at 28 weeks": 736 of the 4,662 people with a pregnancy loss (survey respondents and others, after the age screen) said how far along they were, in the entry that reports the loss. Median 9 weeks; 80.6% in the first trimester (before week 14); 66 at 20 weeks or later, which counts as a stillbirth in the US. Weeks are as people wrote them, usually counted from the last period. Found by matching text patterns, so a few may be misread. Click a bar to list that week's survey respondents (the blue part) on Pregnancy respondents.
Pre-eclampsia
Any spelling ("preeclampsia", "pre-eclampsia", "pre eclampsia", "preclampsia") or HELLP syndrome, its severe form, anywhere in v-safe, plus anyone with a MedDRA pre-eclampsia, eclampsia or HELLP code: 965 from free text, 959 coded, 54 found only by the code: some are misspellings ("preecmplasia"), others have no matching text in the data we have. Only the registrant's own pre-eclampsia, post vaccination: entries that could go either way were read, and a pre-eclampsia in an earlier pregnancy ("with my first son", "in 2018"), a suspected one ("possible preeclampsia", "being monitored for"), or one that was ruled out doesn't count. A code doesn't count when the person's own words about it were all ruled out. See the mentions in Search (the search finds "eclamp", which covers most spellings).
Ectopic pregnancy
An ectopic pregnancy is a pregnancy loss, so this counts the pregnancy losses above that are ectopic ("ectopic", "tubal pregnancy"): the registrant's own, post vaccination. A suspected or ruled-out one ("possible ectopic", "to rule out ectopic") doesn't count, and nor does one before the vaccine. "Ectopic" also describes extra heartbeats, so mentions next to heart words are left out. A MedDRA ectopic pregnancy code counts for someone the pregnancy-loss count includes: 261 from free text, 253 coded, 6 found only by the code: some are misspellings ("etopic"), others have no matching text in the data we have. See the mentions in Search (the search finds "ectopic preg", which covers most of them).
Premature deliveries: how early
Show the numbers
| Weeks | Took the pregnancy survey | Did not | All |
|---|---|---|---|
| 20 | 2 | 0 | 2 |
| 21 | 0 | 2 | 2 |
| 22 | 4 | 1 | 5 |
| 23 | 0 | 1 | 1 |
| 24 | 3 | 3 | 6 |
| 25 | 1 | 3 | 4 |
| 26 | 2 | 3 | 5 |
| 27 | 5 | 3 | 8 |
| 28 | 3 | 4 | 7 |
| 29 | 2 | 6 | 8 |
| 30 | 7 | 5 | 12 |
| 31 | 3 | 4 | 7 |
| 32 | 6 | 4 | 10 |
| 33 | 8 | 13 | 21 |
| 34 | 29 | 29 | 58 |
| 35 | 17 | 21 | 38 |
| 36 | 28 | 18 | 46 |
240 people whose free text gives the week of a premature delivery (before 37 weeks), median 34 weeks: 33 extremely preterm (before 28 weeks), 34 very preterm (28–31), 173 moderate to late (32–36). Read from text like "born at 33 weeks" or "came 6 weeks early" (counted against a 40-week term); "3 weeks early" is 37 weeks, full term, and not counted. For comparison, 257 people have a MedDRA premature delivery or premature baby code.
How early: v-safe compared with US live births in 2019
Show the numbers
| Weeks | v-safe share | 95% CI | v-safe people | US 2019 share | Ratio (95% CI) |
|---|---|---|---|---|---|
| Under 28 weeks | 10.9% | 7.5%–15.6% | 25 | 6.1% | 1.78 (1.22–2.54) |
| 28–31 weeks | 13.9% | 10.0%–19.0% | 32 | 9.0% | 1.54 (1.11–2.1) |
| 32–33 weeks | 13.5% | 9.7%–18.5% | 31 | 11.7% | 1.15 (0.82–1.58) |
| 34–36 weeks | 61.7% | 55.3%–67.8% | 142 | 73.1% | 0.84 (0.76–0.93) |
Each bar is a share of preterm live births only: of the babies born alive before 37 weeks, how many were born in each range. v-safe: the people above who wrote the week of a premature delivery, leaving out the 10 with a stillbirth code (230 left). US 2019: all US live births that year, before COVID-19 vaccines, weighted to the same mix of mothers' ages (source: Births: Final Data for 2019, NCHS, Table 21). Among v-safe preterm births, 24.8% were born before 32 weeks (95% CI 19.6–30.7%), against 15.1% in 2019; before 28 weeks the share was 1.78 times the 2019 share (95% CI 1.22–2.54). This compares how early preterm babies came, not how often babies were born preterm: v-safe has no count of all births. The data cannot say whether the difference reflects which births people chose to write about, or a real shift toward earlier delivery. CDC studies that did count all births found no increase in how often babies were born preterm after vaccination.
Who kept doing check-ins
Show the numbers
| Pregnant at vaccination (n=56,450) | Pregnant after vaccination (n=9,511) | Said not pregnant (n=7,660) | Comparison women (age-standardized) (n=3,221,439) | |
|---|---|---|---|---|
| 3 months | 83.3% (83.0%–83.6%) | 95.3% (94.8%–95.7%) | 82.2% (81.3%–83.0%) | 46.2% (46.1%–46.2%) |
| 6 months | 79.3% (79.0%–79.6%) | 89.8% (89.1%–90.4%) | 78.1% (77.2%–79.0%) | 46.8% (46.8%–46.9%) |
| 12 months | 58.5% (58.1%–58.9%) | 71.9% (71.0%–72.8%) | 60.2% (59.1%–61.3%) | 34.0% (33.9%–34.1%) |
Share with any check-in in the 3-, 6- and 12-month surveys. A loss can only be reported by someone still taking part, and pregnant respondents stayed far more engaged than other women, so they had more chances to report anything.
Not in the survey: pregnancy loss or pregnancy
People who never took the pregnancy survey (it ran only 2021-04-13 to 2021-06-07) but show a pregnancy elsewhere in v-safe: a pregnancy loss post vaccination, or an active MedDRA pregnancy code, a check-in answer "pregnant: Yes", or a call center pregnancy record. The same age screen applies (51+ or under 12 at first dose are left out unless there is a pregnancy loss). "Pregnant: Yes" on a check-in is sometimes a mistaken tap.
| Registrant | Signs | Age at 1st dose | Vaccinations | Check-ins | MedDRA terms | Free text | Call cases | Flags |
|---|---|---|---|---|---|---|---|---|
| 3TG-17121-28074 | check-in: pregnant | 46-50 | 2 | 23 | 3 | 8 | 0 | |
| 3TJ-10769-73597 | check-in: pregnant | 31-35 | 4 | 23 | 5 | 3 | 1 | |
| 3TJ-29199-26170 | MedDRA pregnancy code | 41-45 | 2 | 23 | 5 | 2 | 0 | |
| 3TK-17340-65024 | check-in: pregnant | 36-40 | 2 | 16 | 2 | 2 | 0 | |
| 3TK-17983-16038 | check-in: pregnant | 36-40 | 1 | 3 | 0 | 0 | 0 | |
| 3TK-77093-41080 | MedDRA pregnancy code call center: pregnant | 36-40 | 3 | 18 | 3 | 2 | 1 | |
| 3TL-23744-47794 | check-in: pregnant | 26-30 | 2 | 25 | 7 | 2 | 0 | |
| 3TN-17502-98867 | check-in: pregnant | 31-35 | 3 | 30 | 4 | 2 | 0 | |
| 3TN-27205-59513 | check-in: pregnant call center: pregnant | 31-35 | 2 | 12 | 1 | 1 | 1 | |
| 3TN-31729-70180 | MedDRA pregnancy code | 36-40 | 2 | 16 | 1 | 1 | 0 | |
| 3TN-67165-72678 | check-in: pregnant | 31-35 | 2 | 3 | 0 | 0 | 0 | |
| 3TP-24183-73793 | check-in: pregnant call center: pregnant | 21-25 | 2 | 3 | 0 | 0 | 1 | |
| 3TP-30983-35900 | check-in: pregnant call center: pregnant | 31-35 | 1 | 6 | 0 | 0 | 1 | |
| 3TQ-15260-25665 | check-in: pregnant call center: pregnant | 26-30 | 1 | 9 | 0 | 0 | 1 | |
| 3TQ-19950-59804 | check-in: pregnant | 26-30 | 3 | 1 | 0 | 0 | 0 | |
| 3TQ-31016-57997 | check-in: pregnant | 31-35 | 3 | 19 | 0 | 0 | 0 | |
| 3TR-16933-65507 | check-in: pregnant call center: pregnant | 36-40 | 1 | 1 | 4 | 1 | 1 | ER |
| 3TR-22997-61289 | check-in: pregnant call center: pregnant | 31-35 | 2 | 6 | 0 | 0 | 1 | |
| 3TR-28651-23289 | call center: pregnant | 31-35 | 2 | 8 | 1 | 1 | 1 | |
| 3TT-14056-23242 | check-in: pregnant | 26-30 | 2 | 23 | 0 | 0 | 0 | |
| 3TT-14979-54467 | check-in: pregnant | 31-35 | 2 | 5 | 0 | 0 | 0 | |
| 3TU-23192-34203 | check-in: pregnant | 26-30 | 3 | 39 | 3 | 2 | 0 | |
| 3TU-31798-63920 | check-in: pregnant | 36-40 | 2 | 13 | 0 | 0 | 0 | |
| 3TV-10759-76259 | check-in: pregnant | 31-35 | 4 | 33 | 0 | 0 | 0 | |
| 3TV-30553-43694 | check-in: pregnant | 26-30 | 2 | 7 | 0 | 0 | 0 |
Showing 3,901–3,925 of 69,896.