Pregnancy registry survey
One response per person, collected 2021-04-13 to 2021-06-07 (vsafe_pregnancy_registry_survey_20210413-20210607.xlsx). Age, vaccine, call center and hospital/ER flags come from each person's other v-safe records.
Screened out: respondents aged 51+ at their first dose (5,643 people) are left out of the tiles and charts, except the 2 who show a sign of pregnancy loss. 1,666 respondents have a pregnancy-loss sign (a MedDRA miscarriage/ectopic/stillbirth code, or free text mentioning one); some of them answered "not pregnant" after the loss.
Pregnancy respondents: the full list, with filters →
Comparison group: 3,221,304 women who registered in v-safe for themselves, aged 12-50 at their first dose, with no sign of pregnancy anywhere in v-safe. Their rates are age-standardized to the pregnant group they are compared with. Bars show percentages; the black lines are 95% confidence intervals.
Responses by week
Show the numbers
| Not pregnant at or since vaccination | Pregnant after vaccination | Pregnant at time of vaccination | |
|---|---|---|---|
| 2021-04-12 | 3,933 | 3,597 | 37,501 |
| 2021-04-19 | 1,392 | 1,454 | 9,376 |
| 2021-04-26 | 713 | 1,221 | 3,354 |
| 2021-05-03 | 440 | 916 | 1,939 |
| 2021-05-10 | 446 | 869 | 1,563 |
| 2021-05-17 | 372 | 701 | 1,414 |
| 2021-05-24 | 322 | 663 | 1,180 |
| 2021-05-31 | 43 | 90 | 122 |
| 2021-06-07 | 1 |
When the survey ran, split by the answer to "pregnancy status". Counts, after the age screen.
Which check-in reported the pregnancy loss
Show the numbers
| Dose 1 (n=248) | Dose 2 (n=659) | Dose 3+ (n=44) | |
|---|---|---|---|
| Day 0 | 0 | 10 | 0 |
| Days 1-6 | 49 | 88 | 1 |
| Day 7 | 21 | 32 | 0 |
| Week 2 | 67 | 112 | 2 |
| Week 3 | 56 | 106 | 0 |
| Week 4 | 18 | 76 | 0 |
| Week 5 | 9 | 55 | 2 |
| Week 6 | 6 | 50 | 4 |
| 3 months | 17 | 78 | 7 |
| 6 months | 4 | 43 | 14 |
| 12 months | 1 | 9 | 14 |
951 women pregnant at vaccination with a MedDRA loss code, by the check-in survey that first reported it, colored by the dose that check-in followed. v-safe has no loss date, only the check-in date. The later check-ins cover longer stretches: the 3-month survey picks up anything since week 6 (about 7 weeks), the 6-month survey about 13 weeks, and the 12-month survey about 26 weeks, so their bars hold more time than the weekly ones. Each dose started its own check-in schedule, and the old one mostly stopped. Dose 2 came 3–4 weeks after dose 1 (21 days for Pfizer, 28 for Moderna), so dose-1 check-ins fade after week 3, and the later check-ins are almost all on dose 2's schedule. The color shows which schedule was running when the loss was reported, not necessarily the dose closest to the loss.
Losses reported in the first week, by day
Show the numbers
| Dose 1 (n=49) | Dose 2 (n=98) | Dose 3+ (n=1) | |
|---|---|---|---|
| Day 0 | 0 | 10 | 0 |
| Day 1 | 0 | 7 | 0 |
| Day 2 | 6 | 14 | 0 |
| Day 3 | 7 | 15 | 1 |
| Day 4 | 12 | 16 | 0 |
| Day 5 | 10 | 20 | 0 |
| Day 6 | 14 | 16 | 0 |
The 148 of those losses reported in the day-0 or daily (days 1–6) check-ins, by days after the dose. Day 0 is the day of the shot.
How far along the pregnancy was at the loss
Show the numbers
| Weeks | Took the pregnancy survey | Did not | All |
|---|---|---|---|
| 2 | 1 | 7 | 8 |
| 3 | 2 | 4 | 6 |
| 4 | 9 | 16 | 25 |
| 5 | 21 | 50 | 71 |
| 6 | 39 | 61 | 100 |
| 7 | 28 | 42 | 70 |
| 8 | 46 | 54 | 100 |
| 9 | 29 | 55 | 84 |
| 10 | 25 | 29 | 54 |
| 11 | 16 | 22 | 38 |
| 12 | 11 | 28 | 39 |
| 13 | 6 | 9 | 15 |
| 14 | 3 | 10 | 13 |
| 15 | 7 | 5 | 12 |
| 16 | 6 | 10 | 16 |
| 17 | 5 | 6 | 11 |
| 18 | 8 | 7 | 15 |
| 19 | 7 | 5 | 12 |
| 20 | 8 | 8 | 16 |
| 21 | 3 | 2 | 5 |
| 22 | 8 | 4 | 12 |
| 23 | 1 | 2 | 3 |
| 24 | 3 | 3 | 6 |
| 25 | 4 | 1 | 5 |
| 26 | 0 | 0 | 0 |
| 27 | 3 | 0 | 3 |
| 28 | 2 | 0 | 2 |
| 29 | 1 | 3 | 4 |
| 30 | 2 | 0 | 2 |
| 31 | 0 | 0 | 0 |
| 32 | 1 | 0 | 1 |
| 33 | 0 | 1 | 1 |
| 34 | 0 | 1 | 1 |
| 35 | 1 | 1 | 2 |
| 36 | 1 | 3 | 4 |
| 37 | 1 | 2 | 3 |
| 38 | 1 | 1 | 2 |
| 39 | 1 | 1 | 2 |
| 40 | 0 | 0 | 0 |
| 41 | 0 | 1 | 1 |
| 42 | 0 | 0 | 0 |
From free text like "miscarriage at 7 weeks" or "stillborn at 28 weeks": 764 of the 5,113 people with a pregnancy-loss sign (survey respondents and others, after the age screen) said how far along they were. Median 9 weeks; 79.8% in the first trimester (before week 14); 75 at 20 weeks or later, which counts as a stillbirth in the US. Weeks are as people wrote them, usually counted from the last period. Found by matching text patterns, so a few may be misread. Click a bar to list that week's survey respondents (the blue part) on Pregnancy respondents.
Pre-eclampsia
Any spelling ("preeclampsia", "pre-eclampsia", "pre eclampsia", "preclampsia") or HELLP syndrome, its severe form, anywhere in v-safe, plus anyone with a MedDRA pre-eclampsia, eclampsia or HELLP code: 996 from free text, 965 coded, 54 found only by the code: some are misspellings ("preecmplasia"), others have no matching text in the data we have. A mention can be a current diagnosis or a past one. See them in Search (the search finds "eclamp", which covers most spellings).
Ectopic pregnancy
"Ectopic", "tubal pregnancy" or "cornual pregnancy", anywhere in v-safe. "Ectopic" also describes extra heartbeats, so mentions next to heart words (beats, atrial, PVCs, palpitations) are left out. A mention can be a current one, a past one or a suspected one ("possible ectopic"). Anyone with a MedDRA ectopic pregnancy code is counted too: 272 from free text, 255 coded, 7 found only by the code: some are misspellings ("etopic"), others have no matching text in the data we have. See them in Search (the search finds "ectopic preg", which covers most of them).
Premature deliveries: how early
Show the numbers
| Weeks | Took the pregnancy survey | Did not | All |
|---|---|---|---|
| 20 | 2 | 0 | 2 |
| 21 | 0 | 2 | 2 |
| 22 | 4 | 1 | 5 |
| 23 | 0 | 1 | 1 |
| 24 | 3 | 3 | 6 |
| 25 | 1 | 3 | 4 |
| 26 | 2 | 3 | 5 |
| 27 | 5 | 3 | 8 |
| 28 | 3 | 4 | 7 |
| 29 | 2 | 6 | 8 |
| 30 | 7 | 5 | 12 |
| 31 | 3 | 4 | 7 |
| 32 | 6 | 4 | 10 |
| 33 | 8 | 13 | 21 |
| 34 | 29 | 29 | 58 |
| 35 | 17 | 21 | 38 |
| 36 | 28 | 18 | 46 |
240 people whose free text gives the week of a premature delivery (before 37 weeks), median 34 weeks: 33 extremely preterm (before 28 weeks), 34 very preterm (28–31), 173 moderate to late (32–36). Read from text like "born at 33 weeks" or "came 6 weeks early" (counted against a 40-week term); "3 weeks early" is 37 weeks, full term, and not counted. For comparison, 257 people have a MedDRA premature delivery or premature baby code.
How early: v-safe compared with US live births in 2019
Show the numbers
| Weeks | v-safe share | 95% CI | v-safe people | US 2019 share | Ratio (95% CI) |
|---|---|---|---|---|---|
| Under 28 weeks | 10.9% | 7.5%–15.6% | 25 | 6.1% | 1.78 (1.22–2.54) |
| 28–31 weeks | 13.9% | 10.0%–19.0% | 32 | 9.0% | 1.54 (1.11–2.1) |
| 32–33 weeks | 13.5% | 9.7%–18.5% | 31 | 11.7% | 1.15 (0.82–1.58) |
| 34–36 weeks | 61.7% | 55.3%–67.8% | 142 | 73.1% | 0.84 (0.76–0.93) |
Each bar is a share of preterm live births only: of the babies born alive before 37 weeks, how many were born in each range. v-safe: the people above who wrote the week of a premature delivery, leaving out the 10 with a stillbirth code (230 left). US 2019: all US live births that year, before COVID-19 vaccines, weighted to the same mix of mothers' ages (source: Births: Final Data for 2019, NCHS, Table 21). Among v-safe preterm births, 24.8% were born before 32 weeks (95% CI 19.6–30.7%), against 15.1% in 2019; before 28 weeks the share was 1.78 times the 2019 share (95% CI 1.22–2.54). This compares how early preterm babies came, not how often babies were born preterm: v-safe has no count of all births. The data cannot say whether the difference reflects which births people chose to write about, or a real shift toward earlier delivery. CDC studies that did count all births found no increase in how often babies were born preterm after vaccination.
Who kept doing check-ins
Show the numbers
| Pregnant at vaccination (n=56,450) | Pregnant after vaccination (n=9,511) | Said not pregnant (n=7,661) | Comparison women (age-standardized) (n=3,221,304) | |
|---|---|---|---|---|
| 3 months | 83.3% (83.0%–83.6%) | 95.3% (94.8%–95.7%) | 82.2% (81.3%–83.0%) | 46.2% (46.1%–46.2%) |
| 6 months | 79.3% (79.0%–79.6%) | 89.8% (89.1%–90.4%) | 78.1% (77.2%–79.0%) | 46.8% (46.8%–46.9%) |
| 12 months | 58.5% (58.1%–58.9%) | 71.9% (71.0%–72.8%) | 60.2% (59.1%–61.3%) | 34.0% (33.9%–34.1%) |
Share with any check-in in the 3-, 6- and 12-month surveys. A loss can only be reported by someone still taking part, and pregnant respondents stayed far more engaged than other women, so they had more chances to report anything.
Not in the survey: pregnancy loss or pregnancy
People who never took the pregnancy survey (it ran only 2021-04-13 to 2021-06-07) but show a pregnancy elsewhere in v-safe: a pregnancy-loss sign, or an active MedDRA pregnancy code, a check-in answer "pregnant: Yes", or a call center pregnancy record. The same age screen applies (51+ or under 12 at first dose are left out unless there is a loss sign). "Pregnant: Yes" on a check-in is sometimes a mistaken tap.
| Registrant | Signs | First loss code | Age at 1st dose | Vaccinations | Check-ins | MedDRA terms | Free text | Call cases | Flags |
|---|---|---|---|---|---|---|---|---|---|
| X9R-32586-83380 | loss in free text | 21-25 | 1 | 14 | 2 | 3 | 0 | ||
| XCD-19153-40886 | loss in free text | 66+ | 3 | 7 | 5 | 2 | 1 | ||
| XN5-18198-56588 | loss in free text | 36-40 | 2 | 25 | 7 | 6 | 2 | ||
| XND-35683-94179 | loss in free text | 61-65 | 5 | 49 | 123 | 45 | 13 | ||
| XQP-32732-79158 | loss in free text | 36-40 | 2 | 7 | 1 | 1 | 0 | ||
| XT6-26166-65948 | loss in free text | 31-35 | 2 | 16 | 4 | 2 | 0 | ||
| YDT-42705-83973 | loss in free text | 26-30 | 2 | 12 | 6 | 5 | 0 | ||
| YGX-14097-27720 | loss in free text MedDRA pregnancy code | 31-35 | 2 | 10 | 3 | 1 | 1 | ||
| YHM-13685-81753 | loss in free text | 66+ | 2 | 17 | 6 | 2 | 2 | ||
| YLE-31428-85250 | loss in free text | 51-55 | 3 | 12 | 23 | 7 | 4 | ||
| YM6-16490-73765 | loss in free text call center: pregnant | 26-30 | 4 | 52 | 4 | 4 | 1 | ||
| YPW-32406-73231 | loss in free text | 31-35 | 2 | 21 | 5 | 9 | 0 | ||
| YZU-34855-38993 | loss in free text | 31-35 | 2 | 24 | 4 | 9 | 1 | ||
| Z5X-14492-55545 | loss in free text | 31-35 | 2 | 4 | 1 | 1 | 0 | ||
| Z8R-14023-25532 | loss in free text | 56-60 | 2 | 25 | 5 | 6 | 0 | ||
| ZA2-16345-20428 | loss in free text | 36-40 | 2 | 1 | 1 | 1 | 0 | ||
| ZA6-30165-80812 | loss in free text check-in: pregnant call center: pregnant | 36-40 | 2 | 5 | 3 | 2 | 1 | ||
| ZBM-90911-55075 | loss in free text MedDRA pregnancy code check-in: pregnant | 26-30 | 1 | 12 | 3 | 2 | 0 | ||
| ZHK-22180-39756 | loss in free text MedDRA pregnancy code check-in: pregnant call center: pregnant | 31-35 | 2 | 8 | 2 | 1 | 1 | ||
| ZKR-31979-29201 | loss in free text | 56-60 | 2 | 25 | 2 | 2 | 0 | ||
| ZM4-18132-69759 | loss in free text MedDRA pregnancy code | 31-35 | 2 | 23 | 13 | 5 | 5 | ||
| ZQX-15691-83536 | loss in free text | 41-45 | 4 | 20 | 11 | 7 | 2 |
Showing 3,426–3,447 of 3,447, earliest loss code first.